Ipamorelin

Commonly discussed at 200-300 mcg subcutaneous injection, 1-3 times daily. Often stacked with CJC-1295 (100 mcg CJC-1295 + 200 mcg Ipamorelin nightly). GH peak occurs around 40 minutes post-injection. Listed on WADA Prohibited List.

Selectively binds to and activates GHSR-1a receptors, leading to enhanced cAMP production and stimulation of GHRH neurons, resulting in pulsatile GH release.

Produces robust GH release without significantly stimulating cortisol, prolactin, or ACTH, making it the most selective GH secretagogue known.

GH release stimulates hepatic IGF-1 production, which mediates downstream effects including enhanced protein synthesis, satellite cell activation, and muscle fiber regeneration.

Produces significant, dose-dependent increases in plasma GH levels in both animals and humans, mimicking natural pulsatile GH secretion.

Stimulates GH-mediated lean muscle growth, protein synthesis, and recovery through the GH/IGF-1 axis.

GH release promotes lipolysis and fat metabolism, supporting improved body composition.

GH secretagogues administered before bed can enhance deep sleep phases, aligning with natural nocturnal GH pulses.

Ipamorelin has been shown to induce longitudinal bone growth in rats, suggesting potential bone health benefits mediated by GH/IGF-1.

This study investigated whether ghrelin mimetics, namely anamorelin and ipamorelin, can alleviate we...

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The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor (GPCR) highly expres...

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Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999...

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Magnesium on Examine

Magnesium supports GH release quality during sleep. Deficiency is common and suppresses slow-wave sleep, which is when Ipamorelin works.

Creatine on Examine

Creatine supports the lean mass gains that GH secretagogues facilitate. Best combined with resistance training.

Thorne Creatine Monohydrate

NSF Certified for Sport. Single-ingredient creatine monohydrate without fillers or solvents.