Ipamorelin

Growth Hormone

·712 Da·5 amino acids·C₃₈H₄₉N₉O₅

3Mechanisms

5Benefits

20Studies

3Dosages

Ipamorelin is a synthetic pentapeptide derived from GHRP-1, featuring non-standard amino acids including alpha-aminoisobutyric acid (Aib) and D-2-naphthylalanine (D-2-Nal). It was developed as the first selective growth hormone secretagogue.

Research Dosage Notes

Commonly discussed at 200-300 mcg subcutaneous injection, 1-3 times daily. Often stacked with CJC-1295 (100 mcg CJC-1295 + 200 mcg Ipamorelin nightly). GH peak occurs around 40 minutes post-injection. Listed on WADA Prohibited List.

Mechanisms of Action

Ghrelin receptor (GHSR-1a) agonism

Strong

Selectively binds to and activates GHSR-1a receptors, leading to enhanced cAMP production and stimulation of GHRH neurons, resulting in pulsatile GH release.

GHSR-1a/cAMP/GHRH

Selective GH release

Strong

Produces robust GH release without significantly stimulating cortisol, prolactin, or ACTH, making it the most selective GH secretagogue known.

Pituitary GH axis (selective)

IGF-1-mediated anabolism

Strong

GH release stimulates hepatic IGF-1 production, which mediates downstream effects including enhanced protein synthesis, satellite cell activation, and muscle fiber regeneration.

GH/IGF-1 axis

Benefits

Growth hormone release

Hormonal

Produces significant, dose-dependent increases in plasma GH levels in both animals and humans, mimicking natural pulsatile GH secretion.

Strong

Lean muscle mass

Body Composition

Stimulates GH-mediated lean muscle growth, protein synthesis, and recovery through the GH/IGF-1 axis.

Moderate

Fat loss

Body Composition

GH release promotes lipolysis and fat metabolism, supporting improved body composition.

Moderate

Improved sleep quality

Sleep

GH secretagogues administered before bed can enhance deep sleep phases, aligning with natural nocturnal GH pulses.

Emerging

Bone density support

Recovery

Ipamorelin has been shown to induce longitudinal bone growth in rats, suggesting potential bone health benefits mediated by GH/IGF-1.

Moderate

Dosage Data

Human

Study: This study investigated whether ghrelin mimetics, namely anamorelin and ipamorel... Year: 2024

Human

Study: This study investigated whether ghrelin mimetics, namely anamorelin and ipamorel... Year: 2024

Animal

Study: The ability of the growth hormone secretagogue (GHS) Ipamorelin to counteract th... Year: 2001

Research Studies

2024

This study investigated whether ghrelin mimetics, namely anamorelin and ipamorelin, can alleviate we...

Physiology & behavior · Zengbing Lu, Man P Ngan, Julia Y H Liu, Lingqing Yang, Longl...

2021

Growth Hormone-Releasing Peptide 6 (GHRP-6) (His-(D-Trp)-Ala-Trp-(D-Phe)-Lys-NH2) is an agonist of t...

Fish & shellfish immunology · Liz Hernández, Hanlet Camacho, Adriana Nuñez-Robainas, Danie...

2021

The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor (GPCR) highly expres...

Neuroscience and biobehavioral reviews · María P Cornejo, Emilio R Mustafá, Franco Barrile, Daniela C...

2019

Ghrelin, a growth hormone-releasing peptide that was first discovered in the stomach of rats in 1999...

Peptides · Takeshi Tokudome, Kentaro Otani, Mikiya Miyazato, Kenji Kang...

2018

Growth hormone (GH) increases lean body mass, decreases fat mass, increases exercise tolerance and m...

Sexual medicine reviews · John T Sigalos, Alexander W Pastuszak

This database is for educational and research purposes only. It is not medical advice. Consult a healthcare professional before using any peptide or supplement.