Bremelanotide is a synthetic cyclic heptapeptide derived from the melanocortin peptide hormone alpha-MSH (alpha-melanocyte-stimulating hormone). It is an active metabolite of melanotan II, differing by the absence of the C-terminal amide group.
FDA-approved dose is 1.75 mg subcutaneous injection, self-administered at least 45 minutes before anticipated sexual activity. Used as-needed (PRN), not daily. No more than 1 dose per 24 hours or 8 doses per month. Common side effects include nausea (40%), flushing (20%), and headache (11%).
Mechanisms of Action
2Benefits
3Treatment of hypoactive sexual desire disorder (HSDD)
Sexual HealthFDA-approved for premenopausal women with HSDD. Phase 3 RECONNECT trials demonstrated statistically significant increases in sexual desire and reductions in distress related to low sexual desire compared to placebo.
Erectile dysfunction support
Sexual HealthStudied in men for erectile dysfunction with a central mechanism of action distinct from PDE5 inhibitors. Shows potential in men who do not respond to conventional ED medications.
Increased sexual arousal
Sexual HealthPromotes physiological arousal through central nervous system pathways rather than peripheral vascular mechanisms.
Research Studies
15This review evaluates pharmacologic treatments for female sexual dysfunction (FSD), focusing on hypo...
Clinical obstetrics and gynecology · Andrew How, Christopher Jowdy, Elli Novatcheva, Anita H Clay...
This review aims to provide an overview of pharmacologic management for hypoactive sexual desire dis...
The Annals of pharmacotherapy · Donna Barakeh, Hadil Mdaihly, Lamis R Karaoui
Erectile dysfunction (ED) pathophysiology involves complex interactions between vasculogenic, hormon...
Expert opinion on pharmacotherapy · Vishal Ila, Edoardo Pozzi, Miyuru Gamage, Ranjith Ramasamy
Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells
Anticancer research · Shuhei Suzuki, Chifumi Kitanaka, Masashi Okada
A large body of preclinical and clinical data shows that the central melanocortin system is a promis...
Nature reviews. Endocrinology · Patrick Sweeney, Luis E Gimenez, Ciria C Hernandez, Roger D ...
This database is for educational and research purposes only. It is not medical advice. Consult a healthcare professional before using any peptide or supplement.