Selank

Primarily administered intranasally. Russian clinical formulation: 0.15% solution, 2 drops (75 mcg/drop) per nostril, 3 times daily for up to 14 days. Research dosages: 250-500 mcg per session, 2-3 times daily. Higher doses up to 750-1000 mcg for severe anxiety. Maximum studied: 2700 mcg/day (split across 3 administrations) for up to 21 days. Cycling recommended: 1-3 weeks off between 14-day courses to avoid GABAergic desensitization.

Acts through allosteric modulation of the GABAergic system, influencing the expression of genes involved in GABA neurotransmission. Produces anxiolytic effects similar to benzodiazepines but without sedation, amnesia, or dependence.

Influences concentrations of serotonin, dopamine, and norepinephrine, and induces metabolism of serotonin. This modulation contributes to its anxiolytic and antidepressant-like effects.

Rapidly elevates the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, supporting neuronal growth, synaptic plasticity, and cognitive function.

Modulates the expression of Interleukin-6 (IL-6) and affects the balance of T helper cell cytokines, reflecting its origin as a tuftsin analog with immunomodulatory properties.

Produces anxiolytic effects comparable to low-dose benzodiazepines without the associated side effects of amnesia, withdrawal, or dependence. Enhances the effect of diazepam in animal models of chronic mild stress.

Enhances memory and learning in animal models through BDNF upregulation and monoamine modulation. Promotes cognitive stability and emotional balance through neurotransmitter regulation.

Produces antidepressant-like effects in animal models of depression and anhedonia, likely mediated through serotonergic and dopaminergic modulation.

As a tuftsin analog, modulates immune function through IL-6 regulation and T-helper cell cytokine balance, potentially supporting immune resilience.

Improves adaptive capacity under conditions of chronic unpredictable stress, supporting emotional stability and cognitive performance under pressure.

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, g...

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · Omar F Rahman, Steven J Lee, William A Seeds

Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipi...

Bulletin of experimental biology and medicine · M A Konstantinopolsky, I V Chernyakova, L G Kolik

It was previously thought that inflammation and an immune response were the only factors capable of ...

Current reviews in clinical and experimental pharmacology · Yasenyavskaya A Leonidovna, Samotrueva M Aleksandrovna, Tsib...

There are many nonopioid central nervous system depressant substances that share a gamma-aminobutyri...

Journal of clinical pharmacology · Cassandra R Doyno, C Michael White

The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on...

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · Ya R Panikratova, I S Lebedeva, O Yu Sokolov, A D Rumshiskay...