Sermorelin

Typically administered as subcutaneous injection before bedtime to synergize with natural nocturnal GH pulses. Common starting dose is 200-300 mcg/day, titrated up in 50-100 mcg increments every 2-4 weeks. Therapeutic range is generally 200-500 mcg/day. Previously FDA-approved (as Geref) for pediatric GH deficiency diagnosis and treatment.

Binds to the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells, activating the Gs-alpha/adenylyl cyclase/cAMP pathway to stimulate growth hormone synthesis and secretion.

Promotes GH secretion in physiological pulses rather than continuous elevation, preserving the natural hypothalamic-pituitary feedback loop including somatostatin-mediated negative feedback.

Indirectly raises insulin-like growth factor 1 (IGF-1) levels through endogenous GH release, supporting anabolic and regenerative processes.

Stimulates endogenous GH production, particularly useful in GH-deficient populations. FDA-approved for diagnosis and treatment of pediatric GH deficiency.

Promotes lean muscle mass and may reduce body fat through GH-mediated lipolysis.

When administered before bed, may improve slow-wave sleep duration, coinciding with natural nocturnal GH pulses.

GH and IGF-1 elevation supports connective tissue repair, bone density, and post-exercise recovery.

May counteract age-related decline in GH secretion (somatopause), supporting skin elasticity, energy, and metabolic function.

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