TB-500

Note: This is the full-length Thymosin Beta-4 (43 amino acids), distinct from the TB-500 fragment. Research dosing in preclinical models varies widely. Human clinical trials (e.g., venous stasis ulcers, dry eye) have used topical formulations. Subcutaneous research protocols commonly discuss 2-5 mg administered 1-2 times weekly for 4-8 weeks (loading), then reduced to maintenance. Not FDA-approved for therapeutic use.

Sequesters monomeric G-actin, regulating actin polymerization and enabling cell migration essential for wound healing, angiogenesis, and tissue repair.

Released by platelets and macrophages after injury to reduce inflammatory cytokine expression and suppress excessive inflammatory responses.

Promotes the mobilization, migration, and differentiation of stem and progenitor cells to injury sites, forming new blood vessels and regenerating tissue.

Decreases the number of myofibroblasts in wounds, reducing scar formation and fibrosis while organizing connective tissue for functional healing.

Protects cells from apoptosis following injury, preserving tissue viability during the acute damage phase.

Topical or systemic TB4 increased re-epithelialization by 42% at day 4 and 61% at day 7 in preclinical models, with increased collagen deposition and angiogenesis.

Promotes repair of skin, cornea, heart, and musculoskeletal tissues in animal models. Enhances ligament healing and dermal repair.

Preclinical evidence shows reduced infarct size and improved cardiac function following myocardial ischemia.

Systemic anti-inflammatory effects may benefit chronic inflammatory conditions and post-injury recovery.

Promotes hair follicle development and may stimulate hair growth through stem cell activation in the hair follicle niche.

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Thymosin β

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