CJC-1295

Not FDA-approved; classified as a research chemical. Human studies used 30-60 mcg/kg subcutaneously. Commonly discussed research doses: CJC-1295 without DAC (Mod GRF 1-29) at 100-300 mcg 1-3x daily; CJC-1295 with DAC at 1-2 mg once or twice weekly. Often combined with GHRP peptides like Ipamorelin for synergistic GH release.

Binds to and activates the GHRH receptor on anterior pituitary somatotroph cells, stimulating the synthesis and pulsatile release of growth hormone while preserving natural GH secretion patterns.

Sustained GH release leads to increased hepatic production of insulin-like growth factor 1 (IGF-1), with plasma levels elevated 1.5-3x for 9-11 days after a single injection.

The DAC (Drug Affinity Complex) variant binds covalently to serum albumin via the maleimidopropionic acid linker, extending the half-life to 6-8 days and enabling once-weekly dosing.

A single injection can increase plasma GH levels 2-10x for 6+ days, with preserved pulsatile secretion patterns. Confirmed in human clinical studies.

Elevated GH and IGF-1 support increased lean muscle mass and reduced body fat over time.

Higher GHRH activity increases slow-wave (deep) sleep, contributing to better overnight recovery, reduced soreness, and improved mental clarity.

Elevated GH and IGF-1 support faster recovery from exercise and injuries, and promote connective tissue repair.

The discovery of hypothalamic hormones propelled exciting advances in pharmacotherapy and improved l...

Endocrinology · Nektarios Barabutis, Mohammad S Akhter, Khadeja-Tul Kubra, K...

Growth hormone-releasing hormone (GHRH) is secreted primarily from the hypothalamus, but other tissu...

Cells · Chongxu Zhang, Tengjiao Cui, Renzhi Cai, Medhi Wangpaichitr,...

CJC-1295 is a 30 amino acid peptide-based drug that stimulates the release of growth hormone (GH) fr...

Drug testing and analysis · Mark Timms, Katherine Ganio, Grace Forbes, Simon Bailey, Roh...

Communal online folk pharmacology fuels the drive for short cuts in attaining muscle enhancement, fa...

Substance use & misuse · Marie Claire Van Hout, Evelyn Hearne

In 1976, small peptide growth hormone secretagogues (GHSs) were discovered and found to promote grow...

Experimental biology and medicine (Maywood, N.J.) · Riccarda Granata, Jörgen Isgaard, Giuseppe Alloatti, Ezio Gh...