CJC-1295

Not FDA-approved; classified as a research chemical. Human studies used 30-60 mcg/kg subcutaneously. Commonly discussed research doses: CJC-1295 without DAC (Mod GRF 1-29) at 100-300 mcg 1-3x daily; CJC-1295 with DAC at 1-2 mg once or twice weekly. Often combined with GHRP peptides like Ipamorelin for synergistic GH release.

Binds to and activates the GHRH receptor on anterior pituitary somatotroph cells, stimulating the synthesis and pulsatile release of growth hormone while preserving natural GH secretion patterns.

Sustained GH release leads to increased hepatic production of insulin-like growth factor 1 (IGF-1), with plasma levels elevated 1.5-3x for 9-11 days after a single injection.

The DAC (Drug Affinity Complex) variant binds covalently to serum albumin via the maleimidopropionic acid linker, extending the half-life to 6-8 days and enabling once-weekly dosing.

A single injection can increase plasma GH levels 2-10x for 6+ days, with preserved pulsatile secretion patterns. Confirmed in human clinical studies.

Elevated GH and IGF-1 support increased lean muscle mass and reduced body fat over time.

Higher GHRH activity increases slow-wave (deep) sleep, contributing to better overnight recovery, reduced soreness, and improved mental clarity.

Elevated GH and IGF-1 support faster recovery from exercise and injuries, and promote connective tissue repair.

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Magnesium on Examine

Magnesium supports GH release quality during sleep. Deficiency is common and suppresses slow-wave sleep, which is when Ipamorelin works.

Creatine on Examine

Creatine supports the lean mass gains that GH secretagogues facilitate. Best combined with resistance training.

Thorne Creatine Monohydrate

NSF Certified for Sport. Single-ingredient creatine monohydrate without fillers or solvents.