Dihexa

Oral or sublingual administration: commonly discussed range is 5-30 mg/day, with many protocols starting at 10 mg/day. Exceptionally long half-life (~12 days), so steady-state builds over weeks. Some users cycle 5 days on / 2 days off. No human clinical trials have been conducted with dihexa itself; all efficacy data is from animal studies. Fosgonimeton (phosphate pro-drug) is the form in human clinical trials.

Potentiates hepatocyte growth factor (HGF) and its receptor c-Met, which play a crucial role in synaptic plasticity and neurotrophic support. Dihexa is reported to be ~7 orders of magnitude more potent than BDNF at promoting synaptogenesis.

Stimulates the formation of new synapses in the brain, enhancing neural connectivity and plasticity.

Promotes the growth and development of new neurons, potentially counteracting neurodegenerative processes.

As a small oligopeptide, Dihexa effectively crosses the blood-brain barrier, enabling direct CNS activity after oral or sublingual administration.

Animal studies show significant improvements in learning, memory, and cognitive function. Reversed cognitive deficits in scopolamine-treated rats.

May protect against neurodegeneration by promoting neurotrophic support via the HGF/c-Met pathway. Fosgonimeton (a pro-drug of dihexa) is in clinical trials for Alzheimer's and Parkinson's.

Enhances formation of new synaptic connections, potentially improving neural network function and information processing.

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