Epitalon

Subcutaneous or intramuscular injection: typically 5-10 mg/day for 10-20 consecutive days, repeated once or twice per year. Common protocols include 5 mg daily for 20 days or 10 mg daily for 10 days, with 4-6 month off-cycle periods. Some intermittent protocols use 10 mg on days 1, 5, 9, 13, and 17. Injection sites should be rotated (abdomen, thighs, upper arms).

Induces telomere elongation via increased telomerase activity. Binds selectively to DNA regions rich in CAG and ATTTC repeats in promoter regions of the telomerase gene, upregulating telomerase transcription.

Acts as a molecular modulator that loosens tightly wound chromatin regions, allowing previously silenced genes involved in antioxidant defenses and DNA repair to be reactivated.

Restores age-related decline in melatonin secretion by the pineal gland, demonstrated in both aged monkeys and humans.

Increases activities of superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase in aging animals.

Significantly increased telomere lengths in blood cells of patients aged 60-65 and 75-80 in human clinical studies.

Extended lifespan in mice and rats in animal studies without inducing tumor growth.

Reduced spontaneous tumors and metastases in mouse models, showing oncostatic and anti-metastatic properties.

Restored melatonin secretion in aged monkeys and humans, potentially improving circadian rhythm and sleep quality.

Showed positive clinical effect in 90% of retinitis pigmentosa patients in human studies.

Increased key antioxidant enzyme activities (SOD, GPx, GST) in aging rat models, reducing oxidative damage.

Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, g...

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · Omar F Rahman, Steven J Lee, William A Seeds

Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells...

Biogerontology · Sarah Al-Dulaimi, Ross Thomas, Sheila Matta, Terry Roberts

Epitalon protects against post-ovulatory aging-related damage of mouse oocytes

Aging · Xue Yue, Sai-Li Liu, Jia-Ni Guo, Tie-Gang Meng, Xin-Ran Zhan...

It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal glan...

Molecules (Basel, Switzerland) · Vladimir Khavinson, Francesca Diomede, Ekaterina Mironova, N...

The effects of melatonin and epithalamin on the content of protein and lipid peroxidation products i...

Bulletin of experimental biology and medicine · I I Zamorskii, I Yu Sopova, V Kh Khavinson